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Apolipoprotein(a) Genetic Sequence Variants Associated With Systemic Atherosclerosis and Coronary Atherosclerotic Burden But Not With Venous Thromboembolism

Helgadottir, Anna (author)
Gretarsdottir, Solveig (author)
Thorleifsson, Gudmar (author)
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Holm, Hilma (author)
Patel, Riyaz S. (author)
Gudnason, Thorarinn (author)
Jones, Gregory T. (author)
van Rij, Andre M. (author)
Eapen, Danny J. (author)
Baas, Annette F. (author)
Tregouet, David-Alexandre (author)
Morange, Pierre-Emmanuel (author)
Emmerich, Joseph (author)
Lindblad, Bengt (author)
Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
Gottsäter, Anders (author)
Lund University,Lunds universitet,Vaskulära sjukdomar - kliniska studier,Forskargrupper vid Lunds universitet,Vascular Diseases - Clinical Research,Lund University Research Groups
Kiemeny, Lambertus A. (author)
Lindholt, Jes S. (author)
Sakalihasan, Natzi (author)
Ferrell, Robert E. (author)
Carey, David J. (author)
Elmore, James R. (author)
Tsao, Philip S. (author)
Grarup, Niels (author)
Jorgensen, Torben (author)
Witte, Daniel R. (author)
Hansen, Torben (author)
Pedersen, Oluf (author)
Pola, Roberto (author)
Gaetani, Eleonora (author)
Magnadottir, Hulda B. (author)
Wijmenga, Cisca (author)
Tromp, Gerard (author)
Ronkainen, Antti (author)
Ruigrok, Ynte M. (author)
Blankensteijn, Jan D. (author)
Mueller, Thomas (author)
Wells, Philip S. (author)
Corral, Javier (author)
Manuel Soria, Jose (author)
Carlos Souto, Juan (author)
Peden, John F. (author)
Jalilzadeh, Shapour (author)
Mayosi, Bongani M. (author)
Keavney, Bernard (author)
Strawbridge, Rona J. (author)
Karolinska Institutet
Sabater-Lleal, Maria (author)
Karolinska Institutet
Gertow, Karl (author)
Karolinska Institutet
Baldassarre, Damiano (author)
Nyyssonen, Kristiina (author)
Rauramaa, Rainer (author)
Smit, Andries J. (author)
Mannarino, Elmo (author)
Giral, Philippe (author)
Tremoli, Elena (author)
de Faire, Ulf (author)
Karolinska Institutet
Humphries, Steve E. (author)
Hamsten, Anders (author)
Karolinska Institutet
Haraldsdottir, Vilhelmina (author)
Olafsson, Isleifur (author)
Magnusson, Magnus K. (author)
Karolinska Institutet
Samani, Nilesh J. (author)
Levey, Allan I. (author)
Markus, Hugh S. (author)
Kostulas, Konstantinos (author)
Dichgans, Martin (author)
Berger, Klaus (author)
Kuhlenbaeumer, Gregor (author)
Ringelstein, E. Bernd (author)
Stoll, Monika (author)
Seedorf, Udo (author)
Rothwell, Peter M. (author)
Powell, Janet T. (author)
Kuivaniemi, Helena (author)
Onundarson, Pall T. (author)
Valdimarsson, Einar (author)
Matthiasson, Stefan E. (author)
Gudbjartsson, Daniel F. (author)
Thorgeirsson, Guomundur (author)
Quyyumi, Arshed A. (author)
Watkins, Hugh (author)
Farrall, Martin (author)
Thorsteinsdottir, Unnur (author)
Stefansson, Kari (author)
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 (creator_code:org_t)
Elsevier BV, 2012
2012
English.
In: Journal of the American College of Cardiology. - : Elsevier BV. - 0735-1097 .- 1558-3597. ; 60:8, s. 722-729
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Objectives The purpose of this study is investigate the effects of variants in the apolipoprotein(a) gene (LPA) on vascular diseases with different atherosclerotic and thrombotic components. Background It is unclear whether the LPA variants rs10455872 and rs3798220, which correlate with lipoprotein(a) levels and coronary artery disease (CAD), confer susceptibility predominantly via atherosclerosis or thrombosis. Methods The 2 LPA variants were combined and examined as LPA scores for the association with ischemic stroke (and TOAST [Trial of Org 10172 in Acute Stroke Treatment] subtypes) (effective sample size [n(e)] = 9,396); peripheral arterial disease (n(e) = 5,215); abdominal aortic aneurysm (ne = 4,572); venous thromboembolism (ne = 4,607); intracranial aneurysm (ne = 1,328); CAD (n(e) = 12,716), carotid intima-media thickness (n = 3,714), and angiographic CAD severity (n = 5,588). Results LPA score was associated with ischemic stroke subtype large artery atherosclerosis (odds ratio [OR]: 1.27; p = 6.7 X 10(-4)), peripheral artery disease (OR: 1.47; p = 2.9 x 10(-14)), and abdominal aortic aneurysm (OR: 1.23; p = 6.0 x 10(-5)), but not with the ischemic stroke subtypes cardioembolism (OR: 1.03; p = 0.69) or small vessel disease (OR: 1.06; p = 0.52). Although the LPA variants were not associated with carotid intima-media thickness, they were associated with the number of obstructed coronary vessels (p = 4.8 x 10(-12)). Furthermore, CAD cases carrying LPA risk variants had increased susceptibility to atherosclerotic manifestations outside of the coronary tree (OR: 1.26; p = 0.0010) and had earlier onset of CAD (-1.58 years/allele; p = 8.2 x 10(-8)) than CAD cases not carrying the risk variants. There was no association of LPA score with venous thromboembolism (OR: 0.97; p = 0.63) or intracranial aneurysm (OR: 0.85; p = 0.15). Conclusions LPA sequence variants were associated with atherosclerotic burden, but not with primarily thrombotic phenotypes. (J Am Coll Cardiol 2012; 60: 722-9) (C) 2012 by the American College of Cardiology Foundation

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)

Keyword

association
atherosclerosis
genetic
lipoprotein(a)
thrombosis

Publication and Content Type

art (subject category)
ref (subject category)

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Helgadottir, Ann ...
Gretarsdottir, S ...
Thorleifsson, Gu ...
Holm, Hilma
Patel, Riyaz S.
Gudnason, Thorar ...
show more...
Jones, Gregory T ...
van Rij, Andre M ...
Eapen, Danny J.
Baas, Annette F.
Tregouet, David- ...
Morange, Pierre- ...
Emmerich, Joseph
Lindblad, Bengt
Gottsäter, Ander ...
Kiemeny, Lambert ...
Lindholt, Jes S.
Sakalihasan, Nat ...
Ferrell, Robert ...
Carey, David J.
Elmore, James R.
Tsao, Philip S.
Grarup, Niels
Jorgensen, Torbe ...
Witte, Daniel R.
Hansen, Torben
Pedersen, Oluf
Pola, Roberto
Gaetani, Eleonor ...
Magnadottir, Hul ...
Wijmenga, Cisca
Tromp, Gerard
Ronkainen, Antti
Ruigrok, Ynte M.
Blankensteijn, J ...
Mueller, Thomas
Wells, Philip S.
Corral, Javier
Manuel Soria, Jo ...
Carlos Souto, Ju ...
Peden, John F.
Jalilzadeh, Shap ...
Mayosi, Bongani ...
Keavney, Bernard
Strawbridge, Ron ...
Sabater-Lleal, M ...
Gertow, Karl
Baldassarre, Dam ...
Nyyssonen, Krist ...
Rauramaa, Rainer
Smit, Andries J.
Mannarino, Elmo
Giral, Philippe
Tremoli, Elena
de Faire, Ulf
Humphries, Steve ...
Hamsten, Anders
Haraldsdottir, V ...
Olafsson, Isleif ...
Magnusson, Magnu ...
Samani, Nilesh J ...
Levey, Allan I.
Markus, Hugh S.
Kostulas, Konsta ...
Dichgans, Martin
Berger, Klaus
Kuhlenbaeumer, G ...
Ringelstein, E. ...
Stoll, Monika
Seedorf, Udo
Rothwell, Peter ...
Powell, Janet T.
Kuivaniemi, Hele ...
Onundarson, Pall ...
Valdimarsson, Ei ...
Matthiasson, Ste ...
Gudbjartsson, Da ...
Thorgeirsson, Gu ...
Quyyumi, Arshed ...
Watkins, Hugh
Farrall, Martin
Thorsteinsdottir ...
Stefansson, Kari
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MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
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Karolinska Institutet

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